nūhou

Cetylpyridinium chloride e like me nā mālama ʻana no COVID-19

Ua hōʻike ʻia ka hoʻokolohua i ke alapine kiʻekiʻe loa o nā quinnary ammonium disinfectants ma ke ʻano he lāʻau lapaʻau no nā mea ʻino he nui, e like me nā coronaviruses: ʻo kēia mau hana e ka hoʻopau ʻana i ka uhi lipid pale i uhi ʻia i nā mea ʻino e like me ka hilinaʻi o ka SARS-CoV-2. Paipai nui ʻia nā pūhui ammonium quaternary e pepehi i nā mea ʻino a aia ma kahi o 350 mau huahana ma ka papa inoa ʻo EPA N: nā mea hoʻomaʻemaʻe maʻi no ka hoʻohana kūʻē ʻana iā SARS-CoV-2 (Nā mea hoʻohui. ʻO nā hui disinfectant a me nā manawa pili (pili me nā maʻi he nui) no ka nui o ka disinfecting Ua hōʻike ʻia nā kemika ma ka papa inoa EPA a> hiki i ka 140 ke hoʻopau i ka maʻi i loko o kekahi mau minuke (18).
Ua alakaʻi ʻia kēia ʻike iā mākou i kahi ʻimi nui aku no nā hui ammonium quaternary me ka hana e kūʻē ana i nā coronavirus a me ka hiki ke ʻike ʻia o nā kemika i hoʻāʻo ʻia i loko o ka haukapila a hiki ke hoʻohana ʻia ma ke ʻano he kūpono kūpono no COVID-19. ʻO kekahi o nā disinfectants i hōʻike ʻia he luku i nā mea ʻino (Supplementary Material) a hoʻohana ākea ʻia i nā huahana mālama pilikino ʻo cetylpyridinium chloride. ʻIke ʻia kēia hui i nā holoi waha a helu ʻia e ka FDA ma ke ʻano he Safe Safe (GRAS) e hoʻohana ʻia nei ma ke ʻano he mea antimicrobial no kaʻiʻo a me nā huahana moa (a i 1%). Ua hoʻohana ʻia ʻo Cetylpyridinium chloride i loko o nā hoʻokolohua hoʻokolohua he nui, e like me ka lapaʻau ʻana i nā maʻi hanu e hōʻoia ana i ka hoʻohana ʻana ma ke ʻano he antiviral. Paipai paha ʻo Cetylpyridinium i ka hana ʻole ʻana o ka virus ma ka luku ʻana i ka capsid a ma o kāna hana lysosomotropic, e like me ke kūkākūkā ʻana ma luna, he mea maʻamau no nā pūhui ammonium quaternary Hāpai kēia i ka nīnau inā paha kekahi o nā lāʻau i ʻike ʻia me ka hana antiviral e kūʻē iā SARS-CoV-2 in vitro e like me ke ʻano, ʻo ia ka mea e luku paha lākou i ka capsid virus a me ka hōʻiliʻili ʻana i ka lysosome a i ʻole nā ​​endosome a i ka hope ke pale ʻana i ke komo ʻana o ka viral. Ua ʻōlelo ʻia he mau noiʻi hou i paʻi ʻia hiki ke hoʻoliʻiliʻi ʻia kēia hopena e ka hoʻohana ʻana o nā mea kāohi iā Cathepsin-L. 

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Cetylpyridinium chloride (CPC)

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ʻO nā hui amonium Quaternary me ka hana coronavirus i ʻike ʻia

Molekule

ʻO ka hana anttiviral

Mekanika

Ua ʻae ʻo FDA

Hoʻohana

ʻO Ammonium Chloride Murine coronavirus, hepatitis C, Lysosomotropic Ae Nā hoʻohana like ʻole me ka acidosis metabolic.
ʻO Cetylpyridinium chloride Influenza, hepatitis B, poliovirus 1 ʻO nā pahuhopu capsid a he lysosomotropic ʻAe, GRAS ʻO Antiseptic, mea holoi waha, nā lozenges batuna, nā huahana mālama pilikino, nā mea hoʻomaʻemaʻe a me nā mea ʻē aʻe

Ka manawa o ka manawa: Apr-16-2021